INSULIN-LOADED POLYMERIC MUCOADHESIVE NANOPARTICLES: DEVELOPMENT, CHARACTERIZATION AND CYTOTOXICITY EVALUATION

Insulin-loaded polymeric mucoadhesive nanoparticles: development, characterization and cytotoxicity evaluation

Abstract Mucoadhesive nanoparticles are particularly interesting for delivery through nasal or pulmonary routes, as an approach to overcome the mucociliary clearance.Moreover, these nanoparticles are attractive for peptide and protein delivery, particularly for insulin to treat diabetes, as an alternative to conventional parenteral administration.T

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The Role of Eryptosis in the Pathogenesis of Renal Anemia: Insights From Basic Research and Mathematical Modeling

Red blood cells (RBC) are the most abundant cells in the blood.Despite powerful defense systems against chemical and mechanical stressors, their life span is limited to about 120 days in healthy humans and further shortened in patients with kidney failure.Changes in the cell membrane potential and cation permeability trigger a cascade of events tha

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High positive end expiratory pressure levels affect hemodynamics in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study

Abstract Background To study the effects of different positive end expiratory pressure Beanie (PEEP) on blood pressure and heart function in elderly patients with hypertension.Methods Forty elderly patients above 65 years of age treated with mechanical ventilation were divided into two groups: a control group of non-hypertensive subjects (n = 18) a

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